A number of studies have confirmed that the physical and chemical properties of the solid material will be greatly changed when the solid material is finely pulverized in the process of drug production, so that it is in the micron or even nano-size, which significantly improves the dissolution of the drug, And can reduce the toxic side effects of drugs. Regardless of oral or topical, can significantly improve the efficacy. Especially in the field of Chinese medicine, ultra-fine grinding technology can change the traditional means of traditional Chinese medicine, Chinese herbal medicine by ultra-fine grinding, can be directly used for oral, thus eliminating the Pieces, boiling and other cumbersome process, greatly facilitate the patient Drug use; not only that, the study shows that the amount of ultra-fine after the amount of traditional Chinese medicine, only the equivalent of the original prescription drug consumption of one-tenth, which greatly saves valuable Chinese herbal medicine resources, but also effectively protect the Chinese herbal medicine planting environment. In addition, through the ultra-fine grinding technology, so that insoluble or slightly soluble in water effective products, the cell wall, can significantly improve the bioavailability of drugs. Which for the Chinese medicine to the world to create a new way.
As a new technology, ultra-fine grinding technology from the nineties of last century was gradually been related to China's research departments and the pharmaceutical industry attention, many of the technology theory is still in the ongoing exploration stage. With the measurement technology and crushing theory of continuous improvement and development, "ultra-fine grinding technology and ultra-fine grinder" in China's pharmaceutical industry will be more widely used.
Ultra-fine grinding technology is a new technology in the past decade, it is based on the traditional crushing technology, the concept of crushing will be greatly extended forward. In a variety of ultra-fine grinding machinery and equipment, the current airflow pulverizer (mainly including five basic types: horizontal disc-type air grinder, circulating pipe-type airflow mill, spray-type reverse airflow mill, impact plate target Airflow grinder, fluidized bed airflow pulverizer) in the pharmaceutical industry is more widely used, and in the air flow mill in the fluidized bed airflow ultrafine grinder the most widely used.
There are three kinds of defects in traditional equipment
Large fluidized bed airflow ultrafine grinder host system consists of air compressor, air purifier system, supersonic airflow mill, grading machine, cyclone separator and so on. Medium and small fluidized bed airflow ultrafine grinder, usually supersonic airflow crusher, classifier and cyclone combination into one machine, can greatly save the area, is conducive to the installation, transportation and use.
At present the pharmaceutical industry in the production of the use of fluidized bed air flow ultrafine grinder, although covered with multi-nozzle, fluidized bed, horizontal grading and gas sealing technology to achieve a diversified flow field, laminar flow State and horizontal grading system. However, since the nozzles designed in this pulverizing mode are arranged in a parallel and symmetrical arrangement along the inner wall of the pulverizing chamber, only the shot is formed in a single plane (i.e., the horizontal pair is sprayed) so that the material to be pulverized can only be formed in an approximately planar Within the scope of the smash, which led to the following defects:
First, the bottom of the crushing chamber for the discharge is convenient, are designed into a conical, by the feeding device into the crushing chamber of the material, once falling into the cone below the crushing chamber, the material that entered a blind spot, can not continue To be crushed.
Second, the crushing area is limited to an approximate plane range, the area is narrow, making the material by air entrainment, impact, squeeze and friction opportunities are relatively small.
Third, the traditional structure makes the material in the process of being crushed, the fluidized state is limited to the top of the nozzle, and deposited in the lower part of the crushing chamber material can not form a fluidized state.
The above defects are the main reason for the high energy consumption and low efficiency of the traditional fluidized bed ultrafine airflow pulverizer.
New equipment to achieve "three-dimensional spray"
In view of these defects in the traditional fluidized bed type ultrafine airflow pulverizer, a new generation of fluidized bed airflow ultrafine grinder has been successfully developed by changing the nozzle setting of the traditional pulverizer.
The nozzle of the series is set in the same plane as the periphery of the crushing chamber, forming a certain angle with the plane, and the nozzle is symmetrical downward. At the same time, there is a vertical upward nozzle in the center of the crushing chamber, Converge at one point, and together to zero. This nozzle setting breaks through the drawbacks of the conventional fluidized bed type airflow pulverizer crushing area. Proved by the production practice, compared with the traditional models, the new models in the same energy consumption circumstances, can improve the efficiency of 1 to 2 times, thus greatly reducing the cost of production.
The new model will be crushed by the approximate plane from the development of three-dimensional, greatly expanding the fluidized bed type air grinder crushing area, so that the material to be crushed in the crushing chamber to get more collision, squeeze and mutual friction Opportunity. In addition, since the lower part of the conical bottom of the pulverizing chamber is provided with an upward nozzle, the material falling into the cone of the crushing chamber can be entrained in time by the high-speed air flow emitted by the nozzle and pulverized in time to eliminate the blind area in the cone below the pulverizing chamber. Therefore, from the bottom to the crushing chamber, the feed chamber and the classification chamber under the action of the jet air to form a complete fluidized state. Material in the joint action of several nozzles, into a cone to focus on the moment, was instantly crushed.
In addition to completely changing the nozzle set, but also uses a new seal device, which is different from the traditional models of the dynamic ring seal device or labyrinth seal device, but the use of air-enclosed seal, no running parts, So do not produce wear and tear, so that the operation of the device more stable and more secure.
The new models meet the GMP requirements, operating performance more secure and reliable. Not only the choice of material in strict accordance with the requirements of GMP equipment, structural design is also fully meet the convenience of demolition, automatic cleaning (CIP / SIP) needs. The host by the flange, the live section bolts and fast clamps connected; bearings using multiple sealing devices and special grease, the equipment in the high-speed operation can be long-term stable operation, grease is not spilled from the source to ensure product safety; The control system uses PLC (programmable logic controller) way, through the panel button control, to replace the traditional opening and closing the cumbersome operation of the valve, not only to reduce the labor intensity, but also to improve the intensity of the surface, Also reflects the human design.
Strictly follow the production control
In the choice of application of new pulverizer, the control must do the following aspects of the requirements:
1. Strict control of the amount of feed. Low concentration of materials, the probability of contact between materials is small, the material concentration is high, will affect the air velocity, so the operation should be regarded as air pressure, material properties and the body's own characteristics, strictly control the material feed speed; Its own characteristics to decide, can be used screw feeder, oscillation feeder or star down feeder to ensure that the shredder of indoor energy sources continue to get the supply of materials to meet the material concentration of crushing the room.
2. Optimize the hierarchical structure. Grading is an essential part of the ultrafine comminution system. The most significant feature of the fluidized bed airflow mill is the ability to achieve continuous feed and discharge, to prevent the material from being finely pulverized, resulting in unnecessary energy consumption. Operation should be based on the turbine classification principle, the appropriate increase in the classification wheel diameter, improve speed, reduce air flow, to ensure that the separation of small size separator.
3. Into the ultra-fine grinder of the original material to be as small as possible. To achieve this goal, should be carried out before the ultra-fine comminution, the use of ordinary mechanical pulverizer for pre-grinding treatment, which is to save energy and improve the unit output of the most direct and effective method.
4. Ensure that the equipment of the entire closed system of air tightness requirements, including pipelines, valves, equipment, and other equipment should not be leaked. Which will be valuable aerodynamic energy, concentrated on the nozzle, to ensure a reasonable gas flow rate and pressure to improve the impact probability of particles.
5. Product collection and dust collector to ensure smooth ventilation, should not be too large resistance. This part of the system device to ensure that the collection of qualified products, but also to ensure that the environment requirements, but the equipment is too complex, things will bring too much burden on the overall work.